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Hersteller

Produkt

Wirkstoff

Beschreibung

Status

ABR-Development

Atléan BTCP

BTCP

Tricalcium phosphate suspended in hyaluronic acid

CE mark

Adoderm

Varioderm Fine Line

Varioderm

Varioderm Plus

Varioderm Subdermal

Non Animal Hyaluronic Acid

Concentration 6 mg/ml

Concentration 12 mg/ml

Concentration 18 mg/ml

Concentration 27 mg/ml

Marketed in Europe and other countries.

Alcon Laboratories, Inc.

Silikon 1000

Silicone

Purified, medical grade polydimethylsiloxane oil-1000 cs. For microdroplet injection.

Silikon 1000 is approved by the FDA for retinal detachments, but not for facial filler indications. Off label use only.

Allergan

Zyderm 1

Bovine Collagen

Purified bovine-based collagen 35 mg/ml

Worldwide

Zyderm 2

Purified bovine-based collagen 65 mg/ml

Worldwide

Zyplast

Purified bovine-based collagen 35 mg/ml, crosslinked with glutaraldehyde.

Worldwide

CosmoDerm

Purified human-based collagen 35 mg/ml

Worldwide

Cosmo Plast

Purified human-based collagen 35 mg/ml, crosslinked with glutaraldehyde.

*All collagen products contain 0,3% Lidocain

Worldwide

HydraFill 1-Europe

Purified avian large particle size HA 5,5 mg/ml

CE mark

HydraFill 2-Europe

Non-animal

Hyaluronic Acid

Non-animal, cross linked monophasic hyaluronic acid.

CE mark

HydraFill 3-Europe

Non-animal

Non-animal, cross linked monophasic hyaluronic acid.

CE mark

Juvéderm 24 HV

Hyaluronic Acid

Purified avian large particle size HA 5,5 mg/ml

FDA approved

Juvéderm 30 HV

Non-animal, cross linked monophasic hyaluronic acid.

FDA approved

Juvéderm 30

Non-animal, cross linked monophasic hyaluronic acid.

FDA approved

Anteis S.A.

Esthélis-Soft 20 mg/ml

Hyaluronic Acid

Non-animal 5 phase cross-linked hyaluronic acid with CPM (Cohesive Polydensified Matrix) technology.

Approved in Europe, Canada, Israel, South Korea and other markets globally. CE Pending.

Artes Medical

Artefill

PMMA

20% polymethylmethacrylate (PMMA) – 32 to 40 microns – 80% purified bovine collagen gel and 0.3% lidocaine.

Worldwide

BioForm

Radiesse

CaHA

Synthetic calcium hydroxylapatite (CaHA – 55.7%) microspheres, 25 – 45 microns, suspended in an aquaeous polysaccharide gel (1.3% sodium carboxymethylcellulose USP, 6.4% glycerin USP & 36.6% water USP).

Worldwide

BioForm Medical

(Russia)

Argiform

PAAG

Generation polyacrylamide gel comprised of 95% polyacrylamide and 5% water.

N/A

BioPolymer GmbH & Co. KG

MATRIDEX

MATRIDUR

MATRIGEL

DEAE

Sephadex

MATRIDEX: synthetic hyaluronic acid sodium salt 25 mg, hypromellose 15 mg, positively charged

DHEA sephadex particles 25 mg (cross-linked dextran)

MATRIDUR: synthetic stabalized hyaluronic acid sodium salt 25 mg and hypromellose 5 mg.

MATRIGEL: stabalized HA 12.25 mg.

CE mark – no FDA approval.

ColBar

LifeScience Ltd.

EVOLENCE 30

Porcine

Collagen

35 mg of cross – linked porcine (tendons)

collagen – glycation with a natural sugar – dispersed in a phosphate buffered saline solution. Glymatrix technology provides a collagen molecule free of telopeptides.

Approved in Europe, Canada, Isreal, South Korea and other markets globally. Not yet approved by the FDA. For investigational use only in U. S.

Contura

International A/S

Aquamid

Aquamid Reconstruction

PAAG

2.5 % cross-linked hydrophilic polyacrylamide gel (PAAG) and 97.5% water.

Not yet approved by the FDA – trials under way. For investigational use only in U.S. CE marking: CE 0543 – March 2001. Sold in more than 30 countries around the world.

Dermabiol Institute of Kuhra Vital GmbH

Rhegecoll

PMMA

Rhegecoll: 40% bovine collagen from U.S. calves, 15% A.D.N., 5% embryoblastos (stem cell) 10% polymethacrylate, 15% copolymer 4-G, 15% stabilizer / emulsifier.

Not approved in U.S., worldwide registrations pending.

Dermatech (Paris)

DermaLive

HEMA / EMA

60% stabilized hyaluronic acid plus 40% acrylic hydrogel (hydroxyethylmetacrylate – HEMA and ethylmetacrylate (EMA) co-polymer particles by volume. DermaLive – 200mg 45-65 micro beads, 14.4 mg HA. Dermadeep – 200 mg 80 110 micro beads, 14.4 mg HA.

DermLive – Approved in Europe 1998, Canada 2003. Dermadeep – Approved in Europe 1998, Canada 2003.

Fascia Biosystems

Fascian

Fascia

Human allograft material – fascia, collected from human cadaver donors. Reconstituted with sterile normal saline, 0.5% lidocaine.

Fascian is a tissue product as classified by FDA, there are no off-label uses – hence a physician can use as desired.

FibroGen, Inc.

FG-5017 (rhCIII) – synthetic human collagen (type III).

Human Collagen

Fg-5017 dermal filler is comprised of a cross-linked formulation of recombinant human collagen type III in saline with lidocaine. Formed collagens based on human DNA sequences in yeast cultures.

Pending approval. Completed human safety clinical trial of recombinant human collagen type III. The pivotal efficacy and safety study required

FuHua High Molecular Matter Company, Ltd.

Amazingel

PAAG

Hydrohilic Polyacrylamide Gel.

Approved in Asia – China in 2000.

FzioMed, Inc.

Laresse Dermal Filler

Carboxymethylce-llulose, Polyethylene Oxide

Non-permanent, long lasting, ultra smooth dermal filler, containing no bacterial or animal by-products, no cross-linking chemicals and no gel particles.

CE mark approved.

Isolagen, Inc.

Isolagen

Autologous fibroblast cells

Isolagen – autologous cellular system – cultured human fibroblasts.

Available only in UK. Filed IND with FDA – approved.

Ladoratories ORGe´V

MacDermol S

MacDermol R

Avian Hyaluronic

Acid / Chitosan

MacDermol S – Avian non cross-linked hyaluronic acid (2.1%) sodium chloride.

MacDermol R – Avian cross-linked hyaluronic acid (3.4%) chitosan chondroitin sulphate sodium chloride.

CE mark – no FDA approval.

LVA Pharmaceutical

Hyaluderm

Hyaluronic Acid

Hyaluderm – non cross-linked sodium hyluronate, 2.0% to 2.5%.

CE mark – no FDA approval.

Medicis

Restylane

Restylane Touch

Restylane Perlane

Restylane Sub-Q

NASHA

NSAHA gel – animal hyaluronic acid, stabilized with BDDE. The differentiation is in the size of the NASHA particles, to assure a tissue-tailored rang of products.

Restylane Touch – 500,000 particles per ml.

Restylane – 100,000 particles per ml.

Restylane Perlane – 10,000 particles per ml.

Restylane Sub-Q – 1,000 particles per ml.

Restylane is approved in the U.S. and Canada. Restylane Perlane and Restylane Fine Lines are approved in Canada / pending FDA approval. Sub-Q is in the approval process.

Mentor Corporation in conjunction with Genzyme Corporation

Puragen

Puragen Plus

Prevelle

Prevelle plus

Hyaluronic Acid

Puragen/Puragen Plus: Non-animal derived double cross-linked (DXL technology) hyaluronic acid – 20 mg/ml.

Prevelle/Prevelle Plus: Non animal derived cross-linked hyaluronic acid, 5.5 mg/ml.

Mentor`s Plus products contain lidocaine integrated directly into the formulation.

Puragen/Puragen Plus: Europe clearance – CE mark. FDA clearance pending.

Prevelle/Prevelle Plus: Europe clearance – CE mark. FDA clearance pending.

Merz Pharma GmbH & Co. KgaA

Belotero Soft – 22.5 mg/ml

Belotero Basic – 20 mg/ml

Hyaluronic Acid

Non-animal double phase cross-linked hyaluronic acid – via biofermentation – with CPM (Cohesive Polydensified Matrix) technology.

CE mark – October 2004 – Merz received the marketing rights for Germany, Austria, Switzerland, Russia and Italy from Anteis SA. U.S. approval pending.

Polymekon

BIO-ALCAMID – Face

BIO-ALCAMID – Lips

BIO-ALCAMID – Body

Poly – Acrylamid

BIO-ALCAMID – 96% water and 4% synthetic reticulate polymer (poly-Alkyl-mide). Lips is soft and compact. Face has the same composition (it is not a dilution), Body has the same consistency as the Face from, but contains more material.

BIO-ALCAMID – CE mark in 2001 – no FDA approval.

Bioinblue – Lips

Bioinblue – DeepBlue

PVA

Bioinblue – PVA (polyvinyl alcohol 8%) and water (92%).

Bioinblue – CE mark in 2003 – no FDA approval.

ProCytech SA

Outline Fine

Outline Original

Outline Ultra

Poly-

Acrylamide-co-DADMA

Outline is absorbable poly (acrylamide-co-DADMA) gel.

Approved in Europe

Evolution

Evolution is a mixture of microscopic soft spheres of polyvinyl in a viscoelastic gel of poly (acryl-lamide-co-DADMA) gel

Prollenium Medical Technologies

Revanesse

Revanesse Ultra

ReDexis

Hyaluronic

Acid

Revanesse-cross-linked HA 25 mg,

hypromellose 12,5 mg

Revanesse Ultra-high viscosity, cross-linked,reticulated hyaluronic acid 25 mg, hypromellose 15 mg.

ReDexis-cross-linked reticulated hyaluronic acid 25 mg, hyprmellose 15 mg, dextronomer DEAE 25 mg.

Approved in Canada. U.S.

Approval pending.

Q-Med AB

Restylane

Restylane Touch

Restylane Perlane

Restylane Sub-Q

Restylane Lipp

Restylane Vital

NASHA

NASHA gel- a non animal hyaluronic acid, stabilized with BDDE. The differentiation is in the size of the NASHA particles, to assure a tissue-tailored range of products.

Restylane Touch-500,000 particles per ml.

Restylae-100,000 particles per ml.

Restylane Perlane-10,000 particles per ml.

Restylane Sub-Q-1,000 particles per ml.

Restylane is approved worldwidecwith the exception of Japan. Restylane Perlane, Restylane Sub-Q and Restylane Touch are approved worldwide with the exception of Japan and U.S U.S. approval in progress. Restylane Lipp approved in Europe.

Rofil/Philoderm

REVIDERM

Rofilan

Beautical 2

Beautical 5

Dextran-Sephadex

Hyaluronic Acid

Poly Acrylamide

REVIDERM-25 mg/ml sephadex (Dextran) 40-60 microns, 20 mg/ml cross linked synthetic hyaluronic acid.

Rofilan-20 mg/ml cross linked synthetic hyaluronic acid.

Beautical 2-Polyacrylamid gel.

Beautical 5-Polyacrylamid gel.

Approval in Europe, Canada and most other countries. Not approved in the U.S.

Sanofi-Aventis

Sculptra-U.S., also known as New Fill or New-Filla

PLLA

Poly-L-Lactic acid (PLLA) hydrogel belonging to the family of aliphatic polyesters. Synthesized from corn.

FDA has approved Sculptra as the only product for the restoration and/or correction of the signs of facial fat loss (lipoatrophy).Approved in Europe in 2000 as NewFill-2004 as Sculptra for facial aesthetic use.

Teoxane SA

Teosyal Global actionm

Teosyal Deep Lines

Teosyal Ultra Deep

Teosyal Kiss

Hyaluronic

Acid

Monophasic cross-linked non-animal hyaluronic acid gel macro-molecules-25 mg/ml.

Europe CE mark.U.S. approval in progress.

Uroplasty

Bioplastique

Silicone

Solid silicone microspheres (100 to 400 and 600µ) suspended in a polyvinylpyrrolidone vector.

CE mark